Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells

Emerging evidence suggests that the intracellular clearance system plays a vital role in maintaining homeostasis and in regulating oxidative stress and inflammation in retinal pigment epithelium (RPE) cells. Dysfunctional proteasomes and autophagy in RPE cells have been associated with the pathogene...

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Bibliografski detalji

Glavni autori:	Iswariyaraja Sridevi Gurubaran, Maria Hytti, Kai Kaarniranta, Anu Kauppinen
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2022-06-01
Serija:	Antioxidants
Teme:	aging age-related macular degeneration oxidative stress mitochondrial damage reactive oxygen species cytokines
Online pristup:	https://www.mdpi.com/2076-3921/11/7/1288
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