Studies towards the Design and Synthesis of Novel 1,5-Diaryl-1<i>H</i>-imidazole-4-carboxylic Acids and 1,5-Diaryl-1<i>H</i>-imidazole-4-carbohydrazides as Host LEDGF/p75 and HIV-1 Integrase Interaction Inhibitors

Two targeted sets of novel 1,5-diaryl-1<i>H</i>-imidazole-4-carboxylic acids <b>10</b> and carbohydrazides <b>11</b> were designed and synthesized from their corresponding ester intermediates <b>17</b>, which were prepared via cycloaddition of ethyl isocyanoacetate <b>16</b> and diarylimidoyl chlori...

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Bibliografische gegevens

Hoofdauteurs:	Thompho J. Rashamuse, Muhammad Q. Fish, E. Mabel Coyanis, Moira L. Bode
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	MDPI AG 2021-10-01
Reeks:	Molecules
Onderwerpen:	ethyl 1,5-diaryl-1<i>H</i>-imidazole-4-carboxylates 1,5-diaryl-1<i>H</i>-imidazole-4-carboxylic acids 1,5-diaryl-1<i>H</i>-imidazole-4-carbohydrazides ethyl isocyanoacetate <i>N</i>-aryl-benzimidoyl chlorides HIV-1 integrase
Online toegang:	https://www.mdpi.com/1420-3049/26/20/6203
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