Polydopamine-coated UiO-66 nanoparticles loaded with perfluorotributylamine/tirapazamine for hypoxia-activated osteosarcoma therapy

Abstract Background Hypoxia is a characteristic of solid tumors that can lead to tumor angiogenesis and early metastasis, and addressing hypoxia presents tremendous challenges. In this work, a nanomedicine based on oxygen-absorbing perfluorotributylamine (PFA) and the bioreductive prodrug tirapazami...

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Hauptverfasser:	Hongfang Chen, You Fu, Kai Feng, Yifan Zhou, Xin Wang, Haohan Huang, Yan Chen, Wenhao Wang, Yuanjing Xu, Haijun Tian, Yuanqing Mao, Jinwu Wang, Zhiyuan Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2021-09-01
Schriftenreihe:	Journal of Nanobiotechnology
Schlagworte:	Metal-organic framework (MOF) Tumor hypoxia Photothermal therapy (PTT) Osteosarcoma
Online-Zugang:	https://doi.org/10.1186/s12951-021-01013-0
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