Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.

Trypanosoma brucei variant surface glycoproteins (VSG) are glycosylated by both paucimannose and oligomannose structures which are involved in the formation of a protective barrier against the immune system. Here, we report that the stinging nettle lectin (UDA), with predominant N-acetylglucosamine-...

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Autors principals:	Víctor M Castillo-Acosta, Luis M Ruiz-Pérez, Els J M Van Damme, Jan Balzarini, Dolores González-Pacanowska
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2015-03-01
Col·lecció:	PLoS Neglected Tropical Diseases
Accés en línia:	http://europepmc.org/articles/PMC4351956?pdf=render
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