High prevalence of Pfdhfr–Pfdhps quadruple mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea

Abstract Background Sulfadoxine–pyrimethamine (SP) is recommended for intermittent preventive treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the therapeutic efficacy of the SP. As molecular markers, Pfdhfr (dihydrofolate reductase) and Pfdhps (dihydropteroate synthas...

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Detalhes bibliográficos

Principais autores:	Tingting Jiang, Jiangtao Chen, Hongxia Fu, Kai Wu, Yi Yao, Juan Urbano Monsuy Eyi, Rocio Apicante Matesa, Maximo Miko Ondo Obono, Weixing Du, Huabing Tan, Min Lin, Jian Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-03-01
coleção:	Malaria Journal
Assuntos:	Plasmodium falciparum Sulfadoxine–pyrimethamine Anti-malarial drug resistance Dihydropteroate synthase Dihydrofolate reductase Bioko Island
Acesso em linha:	http://link.springer.com/article/10.1186/s12936-019-2734-x
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