Efficient whole-cell biocatalytic synthesis of 2′-deoxy-2′-fluoroadenosine, a key building block for nucleic acid drugs

2′-Deoxy-2′-fluoroadenosine (2′-F-dA) is a nucleoside analogue used as a key building block for oligonucleotide drugs. It can be biosynthesized from a low-cost 2′-deoxy-2′-fluorouridine via one-pot transglycosylation catalyzed by a thymidine phosphorylase (TP) and a purine nucleoside phosphorylase (...

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Principais autores:	Dandan Feng, Tianshu Zhang, Guan Zhou, Yanli Cao, Quan Luo, Huifang Xu, Xuefeng Lu
Formato:	Artigo
Idioma:	Inglês
Publicado:	KeAi Communications Co., Ltd. 2026-06-01
Series:	Synthetic and Systems Biotechnology
Assuntos:	Nucleoside analogues 2′-deoxy-2′-fluoroadenosine Whole-cell-based biosynthesis Nucleoside phosphorylases Thermal pretreatment
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2405805X25001929
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