AAV-CRISPR-Cas13 eliminates human enterovirus and prevents death of infected miceResearch in context

Summary: Background: RNA viruses account for many human diseases and pandemic events but are often not targetable by traditional therapeutics modalities. Here, we demonstrate that adeno-associated virus (AAV) -delivered CRISPR-Cas13 directly targets and eliminates the positive-strand EV-A71 RNA vir...

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Bibliografische Detailangaben

Hauptverfasser:	Choong Tat Keng, Thinesshwary Yogarajah, Regina Ching Hua Lee, Irfan Bin Hajis Muhammad, Bing Shao Chia, Suraj Rajan Vasandani, Daryl Shern Lim, Ke Guo, Yi Hao Wong, Chee Keng Mok, Justin Jang Hann Chu, Wei Leong Chew
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-07-01
Schriftenreihe:	EBioMedicine
Schlagworte:	Adeno-associated viral vectors CRISPR-Cas13d Bioinformatics Enterovirus Prophylactic Therapeutic
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2352396423002475
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