Mechanisms of multi-organ damage in Wilson disease from the gut-liver-brain axis perspective: copper metabolism, gut microbiota, and metabolite communication

Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B mutations, leading to pathological copper deposition in the liver, brain, and cornea. Although the gut-liver-brain axis plays a role, direct copper accumulation in multiple organs remains the primary cause of...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Xue-Qiao Wang, Yan-Xin Wang, Zhao-Hao Ye, Zhi-Lin Zhang, Si-Fan Cen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-06-01
Edice:	Frontiers in Microbiology
Témata:	copper toxicity gut microbiota microbial metabolites neuroinflammation Wilson disease
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fmicb.2026.1868164/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!