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Effect of Alpha2-Plasmin Inhibitor C-Terminal Heterogeneity on Clot Lysis and Clot Structure

Alpha2-plasmin inhibitor (α2PI) has a heterogeneous structure due to proteolytic cleavages in the circulation. The C-terminally cleaved form loses the plasminogen binding site and is, therefore, a slow plasmin inhibitor (NPB-α2PI). As FXIII primarily crosslinks the plasminogen-binding intact form (P...

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Autori principali: Réka Bogáti, Barbara Baráth, Dóra Pituk, Rita Orbán-Kálmándi, Péter Szűcs, Zoltán Hegyi, Zsuzsanna Bereczky, Zsuzsa Bagoly, Éva Katona
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2025-08-01
Serie:Biomolecules
Soggetti:
alpha2-plasmin inhibitor
antiplasmin
fibrinolysis
clot lysis
confocal laser scanning microscopy
Accesso online:https://www.mdpi.com/2218-273X/15/8/1127
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