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Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation

Recent clinical trials revealed that sodium-glucose co-transporter 2 (SGLT2) inhibitors significantly reduce cardiovascular events in type 2 diabetic patients, however, canagliflozin increased limb amputations, an effect not seen with other SGLT2 inhibitors. Since endothelial cell (EC) dysfunction p...

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Bibliografski detalji
Glavni autori: Ghazaleh Behnammanesh, Zane E. Durante, Kelly J. Peyton, Luis A. Martinez-Lemus, Scott M. Brown, Shawn B. Bender, William Durante
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019-04-01
Serija:Frontiers in Pharmacology
Teme:
Online pristup:https://www.frontiersin.org/article/10.3389/fphar.2019.00362/full
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