Polygenic scores for executive functioning as predictors of performance improvements after repeated testing in major psychiatric disorders

Abstract Executive Functions (EF) control goal-oriented behaviors and are disrupted in patients with psychiatric disorders (PPD). Repeated EF testing in clinical practice and research aims to evaluate disease progression and treatment efficacy. Performance improvements (or “practice effects”) are ex...

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Hauptverfasser:	Alba Navarro-Flores, Maria Heilbronner, Hajar Rafiee, Bernadette Wendel, Sergi Papiol, Kristina Adorjan, Monika Budde, Mojtaba Oraki Kohshour, Eva C. Schulte, Daniela Reich-Erkelenz, Fanny Senner, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Udo Dannlowski, Detlef E. Dietrich, Andreas J. Fallgatter, Christian Figge, Fabian U. Lang, Georg Juckel, Carsten Konrad, Jens Reimer, Eva Z. Reininghaus, Max Schmauß, Andrea Schmitt, Carsten Spitzer, Jens Wiltfang, Jörg Zimmermann, Peter Falkai, Thomas G. Schulze, Urs Heilbronner
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-03-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Genetics Executive function Performance improvement Major psychiatric disorders Polygenic scores Practice effects
Online-Zugang:	https://doi.org/10.1038/s41598-026-41345-1
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