Norharmane prevents muscle aging via activation of SKN-1/NRF2 stress response pathways

Sarcopenia, the age-related decline in muscle mass and function, is a significant contributor to increased frailty and mortality in the elderly. Currently, no FDA-approved treatment exists for sarcopenia. Here, we identified norharmane (NR), a β-carboline alkaloid, as a potential therapeutic agent f...

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Autori principali:	Farida S. Nirmala, Hyunjung Lee, Yejin Cho, Min Young Um, Hyo Deok Seo, Chang Hwa Jung, Jeong-Hoon Hahm, Jiyun Ahn
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-03-01
Serie:	Redox Biology
Soggetti:	Sarcopenia Norharmane Nrf2 SKN-1 Myogenesis Mitochondrial function
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2213231725000254
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