β-Carotene liposome-based responsive hydrogel inhibits palmitoylation to restore intracellular calcium homeostasis for effective periodontitis treatment

Abstract Endoplasmic reticulum (ER) stress is a key pathological mechanism in periodontitis. Our study demonstrates that the periodontitis microenvironment induces ER stress, leading to ER Ca2+ efflux via inositol 1,4,5-trisphosphate receptors (IP3R) and subsequent mitochondrial Ca2+ overload throug...

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Главные авторы:	Shun Huang, Menghan Li, Zishuo Cheng, Minyu He, Jiaju Deng, Danlan Zhang, Miao Tan, Shijia Ding, Haiping Wu, Lan Huang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2025-12-01
Серии:	Journal of Nanobiotechnology
Предметы:	Endoplasmic reticulum stress Calcium overload S-palmitoylation $$\beta$$ -carotene Periodontitis
Online-ссылка:	https://doi.org/10.1186/s12951-025-03973-z
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