Facile Synthesis and In Vitro Activity of <i>N</i>-Substituted 1,2-Benzisothiazol-3(2<i>H</i>)-ones against Dengue Virus NS2BNS3 Protease

Several new <i>N</i>-substituted 1,2-benzisothiazol-3(2<i>H</i>)-ones (BITs) were synthesised through a facile synthetic route for testing their anti-dengue protease inhibition. Contrary to the conventional multistep synthesis, we achieved structurally diverse BITs with excellent yields using a two-...

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Autors principals:	Farwa Batool, Muhammad Saeed, Hafiza Nosheen Saleem, Luisa Kirschner, Jochen Bodem
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2021-04-01
Col·lecció:	Pathogens
Matèries:	dengue virus direct-acting antivirals 1,2-benzisothiazolinone drug discovery infectivity assays
Accés en línia:	https://www.mdpi.com/2076-0817/10/4/464
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