Respiration and ROS production in brain and spinal cord mitochondria of transgenic rats with mutant G93a Cu/Zn-superoxide dismutase gene

Mitochondrial dysfunction is involved in the pathogenesis of motor neuron degeneration in the G93A mutant transgenic (tgmSOD1) animal model of ALS. However, it is unknown whether mitochondriopathy is a primary or secondary event. We isolated brain (BM) and spinal cord (SCM) mitochondria from 2 month...

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Detalhes bibliográficos

Principais autores:	Alexander Panov, Nataliya Kubalik, Natalia Zinchenko, Richelle Hemendinger, Sergey Dikalov, Herbert L. Bonkovsky
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2011-10-01
coleção:	Neurobiology of Disease
Assuntos:	ALS Amyotrophic lateral sclerosis Transgenic SOD1 Oxidative phosphorylation Reactive oxygen species
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996111002014
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