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Alcian blue‐positive stromal phenotype in basal cell carcinoma is associated with progression on first‐line hedgehog inhibitors

Abstract Basal cell carcinoma (BCC) is the most frequent malignancy in fair‐skinned populations. Although curable in most cases, approximately 4% of patients develop locally advanced or metastatic disease (advBCC) requiring systemic therapy. Hedgehog pathway inhibitors (HHIs; vismodegib/sonidegib) c...

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Автори: Viola K DeTemple, Rudolf Stadler, Sabine Bredemeier, Sungyoung Chung, Katrin Schaper‐Gerhardt, Mareike Alter, Yenny Angela, Henner Stege, Ulrike Leiter, Jan Ohletz, Elisabeth Livingstone, Imke vonWasielewski, Jessica C Hassel, Julia Huynh, Christoffer Gebhardt, Claudia Pföhler, Ralf Gutzmer, Christina H Scheel
Формат: Artigo
Мова:Inglês
Опубліковано: Wiley 2026-01-01
Серія:The Journal of Pathology: Clinical Research
Предмети:
basal cell carcinoma
hedgehog inhibitors
vismodegib
sonidegib
tumor stroma
Alcian blue staining
Онлайн доступ:https://doi.org/10.1002/2056-4538.70074
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