FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking
Abstract Fusion oncoproteins, a class of chimeric proteins arising from chromosomal translocations, are major drivers of various pediatric cancers. These proteins are intrinsically disordered and lack druggable pockets, making them highly challenging therapeutic targets for both small molecule-based...
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| Principais autores: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Portfolio
2025-02-01
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| 叢編: | Nature Communications |
| 在線閱讀: | https://doi.org/10.1038/s41467-025-56745-6 |
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