Integration of biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity

Summary: Hundreds of genetic associations for asthma have been identified, yet translating these findings into mechanistic insights remains challenging. We leveraged plasma proteomics from the UK Biobank Pharma Proteomics Project (UKB-PPP) to identify biomarkers and effectors of asthma risk or heter...

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Autori principali:	Lauren J. Donoghue, Christian Benner, Diana Chang, Flaviyan Jerome Irudayanathan, Rion K. Pendergrass, Brian L. Yaspan, Anubha Mahajan, Mark I. McCarthy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-05-01
Serie:	Cell Genomics
Soggetti:	plasma proteomics asthma GWAS causal inference Mendelian Randomization
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2666979X25000965
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