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The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei.

Most mitochondrial mRNAs in trypanosomes undergo uridine insertion/deletion editing that is catalyzed by approximately 20S editosomes. The editosome component KREPA3 is essential for editosome structural integrity and its two zinc finger (ZF) motifs are essential for editing in vivo but not in vitro...

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Hlavní autoři: Xuemin Guo, Nancy Lewis Ernst, Jason Carnes, Kenneth D Stuart
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2010-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC2811742?pdf=render
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