Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

Abstract The capacity to regenerate myelin in the central nervous system diminishes with age. This decline is particularly evident in multiple sclerosis (MS), a chronic demyelinating disease. Whether cellular senescence, a hallmark of aging, contributes to remyelination impairment remains unknown. H...

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Autores principales:	Phillip S. Gross, Violeta Durán-Laforet, Lana T. Ho, George S. Melchor, Sameera Zia, Zeeba Manavi, William E. Barclay, Sung Hyun Lee, Nataliia Shults, Sean Selva, Enrique Alvarez, Jason R. Plemel, Meng-meng Fu, Dorothy P. Schafer, Jeffrey K. Huang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-03-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-025-57632-w
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