Ceramide metabolism alterations contribute to Tumor Necrosis Factor-induced melanoma dedifferentiation and predict resistance to immune checkpoint inhibitors in advanced melanoma patients

IntroductionAdvanced cutaneous melanoma is a skin cancer characterized by a poor prognosis and high metastatic potential. During metastatic spread, melanoma cells often undergo dedifferentiation toward an invasive phenotype, resulting in reduced expression of microphthalmia-associated transcription...

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Main Authors:	Carine Dufau, Matthieu Genais, Elodie Mucher, Benjamin Jung, Virginie Garcia, Anne Montfort, Marie Tosolini, Christopher J. Clarke, Jeffrey A. Medin, Thierry Levade, Jean-Pierre Delord, Nicolas Meyer, Vera Pancaldi, Nathalie Andrieu-Abadie, Bruno Ségui
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2024-07-01
Series:	Frontiers in Immunology
Subjects:	melanoma TNF dedifferentiation sphingolipids biomarkers immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1421432/full
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