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1,2-Dichloroethane induces testicular pyroptosis by activating piR-mmu-1019957/IRF7 pathway and the protective effects of melatonin

1,2-Dichloroethane (1,2-DCE) is a prevalent environmental contaminant, and our study revealed its induction of testicular toxicity in mice upon subacute exposure. Melatonin, a prominent secretory product of the pineal gland, has been shown to offer protection against pyroptosis in male reproductive...

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Principais autores: Bingli Zhang, Yizhou Zhong, Jiaxin Du, Rongyi Ye, Bingchi Fan, Yanhong Deng, Ruobing Bai, Yu Feng, Xiaohong Yang, Yuji Huang, Boxuan Liang, Jiewei Zheng, Weifeng Rong, Xingfen Yang, Zhenlie Huang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-02-01
Serier:Environment International
Fag:
1,2-Dichloroethane
PiRNAs
IRF7
Pyroptosis
Reproductive toxicity
Melatonin
Online adgang:http://www.sciencedirect.com/science/article/pii/S0160412024000667
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