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Altered TDP-43 Structure and Function: Key Insights into Aberrant RNA, Mitochondrial, and Cellular and Systemic Metabolism in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disorder with no cure available and limited treatment options. ALS is a highly heterogeneous disease, whereby patients present with vastly different phenotypes. Despite this heterogeneity, over 97% of patients will exhibit...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Leanne Jiang, Shyuan T. Ngo
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-07-01
Schriftenreihe:Metabolites
Schlagworte:
amyotrophic lateral sclerosis
ALS
TDP-43
RNA
autoregulation
splicing
Online-Zugang:https://www.mdpi.com/2218-1989/12/8/709
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