The addition of PD-1/PD-L1 axis blockade to BRAF and MEK inhibition for advanced melanoma patients harboring BRAF mutations: a systematic review and meta-analysis

Objectives: Immune-checkpoint inhibitors (ICI) and targeted-therapies (TT) have become standard options for BRAF-V600 metastatic melanomas (MM). Recently, randomized trials (RCT) addressed the efficacy of combined approaches, with conflicting results. We sought to evaluate efficacy and safety of fir...

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Main Authors: Mauricio Fernando Silva Almeida Ribeiro, Camila Bragança Xavier, Allan Andresson Lima Pereira, Mariana Scaranti, Luiza Dib Batista Bugiato Faria, Tatiana Strava Correa, Marina Sahade, David Queiroz Borges Muniz, Olavo Feher, Gustavo dos Santos Fernandes, Artur Katz, Rodrigo Ramella Munhoz
Format: Artigo
Sprog:Inglês
Udgivet: Thieme Revinter Publicações Ltda. 2022-10-01
Serier:Brazilian Journal of Oncology
Fag:
melanoma
programmed cell death 1 receptor
proto-oncogene proteins b-raf
map kinase signaling system
immunotherapy
Online adgang:https://www.brazilianjournalofoncology.com.br/details/189/en-US/the-addition-of-pd-1-pd-l1-axis-blockade-to-braf-and-mek-inhibition-for-advanced-melanoma-patients-harboring-braf-mutations--a-systematic-review-and-m
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