Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK)

Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown. In this study, we first described the anxious and...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	David P. Herzog, Natarajan Perumal, Caroline Manicam, Giulia Treccani, Jens Nadig, Milena Rossmanith, Jan Engelmann, Tanja Jene, Annika Hasch, Michael A. van der Kooij, Klaus Lieb, Nils C. Gassen, Franz H. Grus, Marianne B. Müller
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Elsevier 2021-11-01
سلاسل:	Neurobiology of Stress
الموضوعات:	Antidepressant CSF Ketamine (2R,6R)-Hydroxynorketamine Proteomics Glucocorticoid receptor signaling
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S2352289521001120
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!