Deep Sequencing of MHC-Adapted Viral Lines Reveals Complex Recombinational Exchanges With Endogenous Retroviruses Leading to High-Frequency Variants

Experimental evolution (serial passage) of Friend virus complex (FVC) in mice demonstrates phenotypic adaptation to specific host major histocompatibility complex (MHC) genotypes. These evolved viral lines show increased fitness and virulence in their host-genotype-of-passage, but display fitness an...

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Principais autores:	Earl A. Middlebrook, Derek L. Stark, Douglas H. Cornwall, Jason L. Kubinak, Wayne K. Potts
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-08-01
coleção:	Frontiers in Genetics
Assuntos:	recombination ERV host adaptation serial passage Friend virus complex murine leukemia virus
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fgene.2021.716623/full
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