Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity.

Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme family in mice results in important joint and bone abnormalities, suggesting a role in skeletal development. As such, the cont...

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Autori principali:	Blandine Poulet, Ke Liu, Darren Plumb, Phoung Vo, Mittal Shah, Katherine Staines, Alexandra Sampson, Hiroyuki Nakamura, Hideaki Nagase, Alessandra Carriero, Sandra Shefelbine, Andrew A Pitsillides, George Bou-Gharios
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2016-01-01
Serie:	PLoS ONE
Accesso online:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0167971&type=printable
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