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Prevalence of anti-lymphocyte IgM autoantibodies driving complement activation in COVID-19 patients

IntroductionCOVID-19 patients can develop autoantibodies against a variety of secreted and membrane proteins, including some expressed on lymphocytes. However, it is unclear what proportion of patients might develop anti-lymphocyte antibodies (ALAb) and what functional relevance they might have.Meth...

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Principais autores: Ainhoa Pérez-Díez, Xiangdong Liu, Stephanie Calderon, Ashlynn Bennett, Andrea Lisco, Anela Kellog, Frances Galindo, Matthew J. Memoli, Joseph M. Rocco, Brian P. Epling, Elizabeth Laidlaw, Mike C. Sneller, Maura Manion, Glenn W. Wortmann, Rita Poon, Princy Kumar, Irini Sereti
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-04-01
coleção:Frontiers in Immunology
Assuntos:
COVID-19
autoantibodies
complement deposition
anti-lymphocyte Ab
lymphopenia
convalescent COVID-19
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1352330/full
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