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Effects of mutations conferring pyrazinamide resistance among multidrug-resistant tuberculosis isolates from China

ABSTRACT To investigate the effects of mutations on pyrazinamide (PZA)-associated regions, including pncA, rpsA, panD, and clpC1, among multidrug-resistant tuberculosis (MDR-TB) isolates from China. A total of 139 MDR-TB isolates from China underwent PZA susceptibility testing and genotyping, and th...

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Principais autores: Xiang-long Bo, Ma-chao Li, Hao Hang, Shi-qiang Lin, Hai-can Liu, Cheng Qian, Gui-lian Li, Xiu-qin Zhao, Kang-Lin Wan, Li-li Zhao
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-07-01
Serier:Microbiology Spectrum
Fag:
multidrug-resistant tuberculosis
pyrazinamide resistance
mutation
gene
Online adgang:https://journals.asm.org/doi/10.1128/spectrum.00641-26
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