Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin

IntroductionHepatotoxicity induced by immunotherapeutics is an appearing cause for immune-mediated drug-induced liver injury. Such immuno-toxic mechanisms are difficult to assess using current preclinical models and the incidence is too low to detect in clinical trials. As hepatotoxicity is a freque...

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Główni autorzy:	Luise A. Roser, Sonja Luckhardt, Nicole Ziegler, Dominique Thomas, Pia Viktoria Wagner, Georg Damm, Andrea Scheffschick, Philip Hewitt, Michael J. Parnham, Susanne Schiffmann
Format:	Artigo
Język:	Inglês
Wydane:	Frontiers Media S.A. 2023-11-01
Seria:	Frontiers in Immunology
Hasła przedmiotowe:	immune-related adverse events immunotherapy in vitro prognostics triple-culture model immune cells
Dostęp online:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275368/full
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