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Oxidation of Phe454 in the Gating Segment Inactivates Trametes multicolor Pyranose Oxidase during Substrate Turnover.

The flavin-dependent enzyme pyranose oxidase catalyses the oxidation of several pyranose sugars at position C-2. In a second reaction step, oxygen is reduced to hydrogen peroxide. POx is of interest for biocatalytic carbohydrate oxidations, yet it was found that the enzyme is rapidly inactivated und...

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Detalhes bibliográficos
Principais autores: Petr Halada, Dagmar Brugger, Jindrich Volc, Clemens K Peterbauer, Christian Leitner, Dietmar Haltrich
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2016-01-01
Colecção:PLoS ONE
Acesso em linha:https://doi.org/10.1371/journal.pone.0148108
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