ABCA6 Regulates Chondrogenesis and Inhibits Joint Degeneration via Orchestrated Cholesterol Efflux and Cellular Senescence

Abstract Patellar dysplasia (PD) can cause patellar dislocation and subsequent osteoarthritis (OA) development. Herein, a novel ABCA6 mutation contributing to a four‐generation family with familiar patellar dysplasia (FPD) is identified. In this study, whole exome sequencing (WES) and genetic linkag...

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Päätekijät:	Yi Wang, Qiang Wu, Yongqing You, Wenbo Jiang, Peiliang Fu, Kerong Dai, Ye Sun
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Wiley 2025-03-01
Sarja:	Advanced Science
Aiheet:	ABCA6 cellular senescence cholesterol efflux chondrogenesis osteoarthritis patellar dysplasia
Linkit:	https://doi.org/10.1002/advs.202410414
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