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Mitochondrial Functions Are Compromised in CD4 T Cells From ART-Controlled PLHIV

The hallmark of HIV/AIDS is a gradual depletion of CD4 T cells. Despite effective control by antiretroviral therapy (ART), a significant subgroup of people living with HIV (PLHIV) fails to achieve complete immune reconstitution, deemed as immune non-responders (INRs). The mechanisms underlying incom...

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Principais autores: Juan Zhao, Madison Schank, Ling Wang, Zhengke Li, Lam Nhat Nguyen, Xindi Dang, Dechao Cao, Sushant Khanal, Lam Ngoc Thao Nguyen, Bal Krishna Chand Thakuri, Stella C. Ogbu, Zeyuan Lu, Xiao Y. Wu, Zheng D. Morrison, Mohamed El Gazzar, Ying Liu, Jinyu Zhang, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-05-01
Colecção:Frontiers in Immunology
Assuntos:
HIV
immune non-responder
mitochondrial dysfunction
T cell exhaustion
senescence
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2021.658420/full
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