Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation

Non-small-cell lung cancer (NSCLC) cell lines vary in their sensitivity to glutaminase inhibitors, so it is important to identify the metabolic assets underling their efficacy in cancer cells. Even though specific genetic lesions such as in KRAS and LKB1 have been associated with reliance on glutami...

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Autori principali:	Elisa Caiola, Marika Colombo, Giovanna Sestito, Monica Lupi, Mirko Marabese, Roberta Pastorelli, Massimo Broggini, Laura Brunelli
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2020-07-01
Serie:	Cells
Soggetti:	NSCLC glutaminase inhibition metabolism alanine uptake cancer cell resistance alanine aminotransferase
Accesso online:	https://www.mdpi.com/2073-4409/9/8/1766
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