Modification of Boc-Protected CAN508 via Acylation and Suzuki-Miyaura Coupling
The cyclin-dependent kinase inhibitor, CAN508, was protected with di-tert-butyl dicarbonate to access the amino-benzoylated pyrazoles. The bromo derivatives were further arylated by Suzuki-Miyaura coupling using the XPhos Pd G2 pre-catalyst. The coupling reaction provided generally the para-substitu...
Bewaard in:
| Hoofdauteurs: | , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
MDPI AG
2018-01-01
|
| Reeks: | Molecules |
| Onderwerpen: | |
| Online toegang: | http://www.mdpi.com/1420-3049/23/1/149 |
| Tags: |
Geen labels, Wees de eerste die dit record labelt!
|