Regulation of EZH2 protein stability: new mechanisms, roles in tumorigenesis, and roads to the clinic

Summary: The importance of EZH2 as a key methyltransferase has been well documented theoretically. Practically, the first EZH2 inhibitor Tazemetostat (EPZ6438), was approved by FDA in 2020 and is used in clinic. However, for most solid tumors it is not as effective as desired and the scope of clinic...

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Bibliografiske detaljer

Principais autores:	Yunyun Guo, Rui Cheng, Yuqing Wang, Maria E. Gonzalez, Hongshan Zhang, Yang Liu, Celina G. Kleer, Lixiang Xue
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2024-02-01
Serier:	EBioMedicine
Fag:	EZH2 Post-translational modification Protein stability Targeted cancer therapy
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2352396424000070
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