Development and validation of a next-generation sequencing-based method for calculating the breast cancer polygenic risk score PRS313

Polygenic risk scores (PRS) are genetic tools that quantify an individual's predisposition to certain diseases by combining the effects of many genetic variants. The PRS313 includes 313 genomic variants and has been incorporated into the BOADICEA prediction model and in the CanRisk software to refin...

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Үндсэн зохиолчид:	Flora Ponelle-Chachuat, Mathis Lepage, Sandrine Viala, Mikaïl Kelleci, Edith Le Floch, Claire Dandine-Roulland, Delphine Bacq, Robert Olaso, Jean-François Deleuze, Nancy Uhrhammer, Mathilde Gay-Bellile, Yannick Bidet, Maud Privat
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2025-12-01
Цуврал:	Breast
Нөхцлүүд:	Polygenic risk score Breast cancer NGS OncoArray PRS313
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S0960977625005971
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