A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle
Abstract The transporter associated with antigen processing (TAP) translocates antigenic peptides into the endoplasmic reticulum (ER) lumen for loading onto MHC class I molecules. This is a key step in the control of viral infections through CD8+ T-cells. The herpes simplex virus type-1 encodes an 8...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2017-06-01
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| Serie: | Scientific Reports |
| Accesso online: | https://doi.org/10.1038/s41598-017-02994-5 |
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