Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men

Summary: Lack of interleukin-6 (IL-6) leads to expansion of adipose tissue mass in rodents and humans. The exact underlying mechanisms have not been identified. In this placebo-controlled, non-randomized, participant-blinded crossover study, we use the IL-6 receptor antibody tocilizumab to investiga...

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Hlavní autoři:	Beckey Trinh, Merel Peletier, Casper Simonsen, Peter Plomgaard, Kristian Karstoft, Bente Klarlund Pedersen, Gerrit van Hall, Helga Ellingsgaard
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2021-09-01
Edice:	Cell Reports Medicine
Témata:	Interleukin-6 tocilizumab IL-6 receptor obesity exercise metabolism
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2666379121002548
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