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Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study

Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD. We used successfully generated KBD human ind...

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Principais autores: Yanan Zhang, Huan Liu, Xialu Lin, Feng’e Zhang, Peilin Meng, Sijia Tan, Mikko J. Lammi, Xiong Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-08-01
coleção:Frontiers in Genetics
Assuntos:
Kashin–Beck disease
HT-2 toxin
cell cycle
cell apoptosis
p53
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgene.2021.677723/full
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