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Efficacy Evaluation of an Intradermally Delivered Enterotoxigenic <i>Escherichia coli</i> CF Antigen I Fimbrial Tip Adhesin Vaccine Coadministered with Heat-Labile Enterotoxin with LT(R192G) against Experimental Challenge with Enterotoxigenic <i>E. coli</i> H10407 in Healthy Adult Volunteers

Background. Enterotoxigenic <i>E. coli</i> (ETEC) is a principal cause of diarrhea in travelers, deployed military personnel, and children living in low to middle-income countries. ETEC expresses a variety of virulence factors including colonization factors (CF) that facilitate adherence to the inte...

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Autori principali: Ramiro L. Gutiérrez, Chad K. Porter, Clayton Harro, Kawsar Talaat, Mark S. Riddle, Barbara DeNearing, Jessica Brubaker, Milton Maciel, Renee M. Laird, Steven Poole, Subra Chakraborty, Nicole Maier, David A. Sack, Stephen J. Savarino
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2024-01-01
Serie:Microorganisms
Soggetti:
enterotoxigenic <i>E. coli</i>
CfaE
intradermal
vaccine
efficacy
H10407
Accesso online:https://www.mdpi.com/2076-2607/12/2/288
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