Targeted Phenotypic Screening in <named-content content-type="genus-species">Plasmodium falciparum</named-content> and <named-content content-type="genus-species">Toxoplasma gondii</named-content> Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules

ABSTRACT The Malaria Box collection includes 400 chemically diverse small molecules with documented potency against malaria parasite growth, but the underlying modes of action are largely unknown. Using complementary phenotypic screens against Plasmodium falciparum and Toxoplasma gondii, we report p...

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Detalles Bibliográficos

Principais autores:	Gowtham Subramanian, Meenakshi A. Belekar, Anurag Shukla, Jie Xin Tong, Ameya Sinha, Trang T. T. Chu, Akshay S. Kulkarni, Peter R. Preiser, D. Srinivasa Reddy, Kevin S. W. Tan, Dhanasekaran Shanmugam, Rajesh Chandramohanadas
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology 2018-02-01
Series:	mSphere
Assuntos:	MMV Malaria Box malaria Plasmodium falciparum Toxoplasma gondii apicoplast chemical phenotyping
Acceso en liña:	https://journals.asm.org/doi/10.1128/mSphere.00534-17
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