Ligand binding drives proteolysis of the SmcR master transcription factor and controls quorum sensing-state transitions in Vibrio species

ABSTRACT In Vibrio species, quorum sensing signaling culminates in the production of the master transcription factor SmcR that regulates group behavior genes in a density-dependent manner. Previously, we identified a small-molecule thiophenesulfonamide inhibitor called PTSP [3-phenyl-1-(thiophen-2-y...

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Detalhes bibliográficos

Principais autores:	Tanmaya A. Rasal, Caleb P. Mallery, Biqing Liang, Matthew W. Brockley, Chelsea A. Simpson, Abigail D. Padgett, Logan J. Geyman, Finley J. Andrew, Laura C. Brown, Jon E. Paczkowski, Julia C. van Kessel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2026-03-01
coleção:	mBio
Assuntos:	quorum sensing quorum sensing inhibitors Vibrio vulnificus Vibrio SmcR thiophenesulfonamides
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.03445-25
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