Causal modeling using network ensemble simulations of genetic and gene expression data predicts genes involved in rheumatoid arthritis.

Tumor necrosis factor α (TNF-α) is a key regulator of inflammation and rheumatoid arthritis (RA). TNF-α blocker therapies can be very effective for a substantial number of patients, but fail to work in one third of patients who show no or minimal response. It is therefore necessary to discover new m...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Heming Xing, Paul D McDonagh, Jadwiga Bienkowska, Tanya Cashorali, Karl Runge, Robert E Miller, Dave Decaprio, Bruce Church, Ronenn Roubenoff, Iya G Khalil, John Carulli
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Public Library of Science (PLoS) 2011-03-01
Sarja:	PLoS Computational Biology
Linkit:	http://europepmc.org/articles/PMC3053315?pdf=render
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