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miR-329– and miR-495–mediated Prr7 down-regulation is required for homeostatic synaptic depression in rat hippocampal neurons

In rat hippocampal neurons, miRNA-dependent regulation of the synaptic Prr7 protein is required for the homeostatic synaptic depression of excitatory synapses upstream of the CDK5-SPAR pathway. Homeostatic synaptic depression (HSD) in excitatory neurons is a cell-autonomous mechanism which protects...

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Principais autores: Michiko O Inouye, David Colameo, Irina Ammann, Jochen Winterer, Gerhard Schratt
Format: Artigo
Sprog:Inglês
Udgivet: Life Science Alliance LLC 2022-12-01
Serier:Life Science Alliance
Online adgang:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201520
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