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The Effect of Ex Vivo Human Serum from Liver Disease Patients on Cellular Protein Synthesis and Growth

Sarcopenia is a common complication affecting liver disease patients, yet the underlying mechanisms remain unclear. We aimed to elucidate the cellular mechanisms that drive sarcopenia progression using an in vitro model of liver disease. C2C12 myotubes were serum and amino acid starved for 1-h and s...

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Автори: Sophie L. Allen, Alex P. Seabright, Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity R. Williams, Nicholas H. F. Fine, David J. Hodson, Matthew J. Armstrong, Ahmed M. Elsharkaway, Carolyn A. Greig, Yu-Chiang Lai, Janet M. Lord, Gareth G. Lavery, Leigh Breen
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2022-03-01
Серія:Cells
Предмети:
chronic liver disease
sarcopenia
leucine
mitochondria
protein breakdown
Онлайн доступ:https://www.mdpi.com/2073-4409/11/7/1098
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