Functional significance of calcium binding to tissue-nonspecific alkaline phosphatase.
The conserved active site of alkaline phosphatases (AP) contains catalytically important Zn2+ (M1 and M2) and Mg2+-sites (M3) and a fourth peripheral Ca2+ site (M4) of unknown significance. We have studied Ca2+ binding to M1-4 of tissue-nonspecific AP (TNAP), an enzyme crucial for skeletal mineraliz...
Gardado en:
| Principais autores: | , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Acceso en liña: | http://europepmc.org/articles/PMC4361680?pdf=render |
| Tags: |
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|