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Case Report: Severe HHV-6-related encephalitis following anti-CD19 CAR-T therapy with no evidence of HHV-6 reactivation in transduced CAR-T cells

We report a case of severe encephalitis caused by human herpes virus 6 (HHV-6) following CD19 chimeric antigen receptor T (CAR-T) cell therapy. Rapid expansion of circulating T-lymphocytes and high HHV-6 viral load (4,500,000 DNA copies/mL) early after CAR-T infusion suggested HHV-6 transferal from...

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Principais autores: Nina Marie Birk, Katrine Kielsen, Özcan Met, Eva Kannik Haastrup, Thomas M. Hulen, Cecilie Ø. Madsen, Torben Barington, Jonas Nielsen, Kristian Schønning, Søren Lykke Petersen, Marianne Ifversen
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2025-09-01
Series:Frontiers in Hematology
Assuntos:
CAR-T therapy
HHV-6
encephalitis
ICANS
neurotoxicity
Acceso en liña:https://www.frontiersin.org/articles/10.3389/frhem.2025.1628552/full
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