Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice

IntroductionSevere injury, including burn trauma, leads to profound immune dysfunction, yet the mechanisms driving these changes remain incompletely defined. This lack of understanding has hindered efforts to modulate the immune response effectively. Additionally, a clear biomarker profile to guide...

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Autori principali:	Micah L. Willis, Roland F. Seim, Laura E. Herring, Angie L. Mordant, Thomas S. Webb, Gilbert R. Upchurch, Ashish K. Sharma, Bruce A. Cairns, Philip A. Efron, Shannon M. Wallet, Leon G. Coleman, Robert Maile
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-06-01
Serie:	Frontiers in Immunology
Soggetti:	burn injury extracellular vesicles thermal injury macrophages microvesicles exosomes
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1596598/full
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