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Efficacy of rigosertib, a small molecular RAS signaling disrupter for the treatment of KRAS-mutant colorectal cancer

Objective: Mutant KRAS, the principal isoform of RAS, plays a pivotal role in the oncogenesis of colorectal cancer by constitutively activating the RAF/MEK/ERK and PI3K/AKT pathways. Effective targeted therapies are urgently needed. We investigated whether rigosertib, a benzyl styryl sulfone RAS sig...

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Principais autores: Xinyi Zhou, Qian Xiao, Dongliang Fu, Haochen Zhang, Yang Tang, Jinjie He, Yeting Hu, Xiangxing Kong, Fei Teng, Xiangrui Liu, Ying Yuan, Kefeng Ding
Formato: Artigo
Idioma:Inglês
Publicado em: China Anti-Cancer Association 2022-02-01
coleção:Cancer Biology & Medicine
Assuntos:
colorectal cancer
kras mutation
rigosertib
therapeutic effect
ras signaling
Acesso em linha:http://www.cancerbiomed.org/index.php/cocr/article/view/1934
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